Proximal tubule PPARα attenuates renal fibrosis and inflammation caused by unilateral ureteral obstruction

We examined the effects of increased expression of proximal tubule peroxisome proliferator-activated receptor (PPAR)α in a mouse model of renal fibrosis. After 5 days of unilateral ureteral obstruction (UUO), PPARα expression was significantly reduced in kidney tissue of wild-type mice but this down...

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Detalhes bibliográficos
Main Authors: Li, Shenyang, Mariappan, Nithya, Megyesi, Judit, Shank, Brian, Kannan, Krishnaswamy, Theus, Sue, Price, Peter M., Duffield, Jeremy S., Portilla, Didier
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3761210/
https://ncbi.nlm.nih.gov/pubmed/23804447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00309.2013
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