Zeta Inhibitory Peptide Disrupts Electrostatic Interactions That Maintain Atypical Protein Kinase C in Its Active Conformation on the Scaffold p62

Atypical protein kinase C (aPKC) enzymes signal on protein scaffolds, yet how they are maintained in an active conformation on scaffolds is unclear. A myristoylated peptide based on the autoinhibitory pseudosubstrate fragment of the atypical PKCζ, zeta inhibitory peptide (ZIP), has been extensively...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Tsai, Li-Chun Lisa, Xie, Lei, Dore, Kim, Xie, Li, Del Rio, Jason C., King, Charles C., Martinez-Ariza, Guillermo, Hulme, Christopher, Malinow, Roberto, Bourne, Philip E., Newton, Alexandra C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2015
Soggetti:
Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4571940/
https://ncbi.nlm.nih.gov/pubmed/26187466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.676221
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