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Electrostatic and Hydrophobic Interactions Differentially Tune Membrane Binding Kinetics of the C2 Domain of Protein Kinase Cα

The cellular activation of conventional protein kinase C (PKC) isozymes is initiated by the binding of their C2 domains to membranes in response to elevations in intracellular Ca(2+). Following this C2 domain-mediated membrane recruitment, the C1 domain binds its membrane-embedded ligand diacylglyce...

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Detalhes bibliográficos
Main Authors: Scott, Angela M., Antal, Corina E., Newton, Alexandra C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675623/
https://ncbi.nlm.nih.gov/pubmed/23589289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.467456
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