Intramolecular C2 Domain-Mediated Autoinhibition of Protein Kinase C βII

The signaling output of protein kinase C (PKC) is exquisitely controlled, with its disruption resulting in pathophysiologies. Identifying the structural basis for autoinhibition is central to developing effective therapies for cancer, where PKC activity needs to be enhanced, or neurodegenerative dis...

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Bibliografische gegevens
Gepubliceerd in:Cell Rep
Hoofdauteurs: Antal, Corina E., Callender, Julia A., Kornev, Alexandr P., Taylor, Susan S., Newton, Alexandra C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4551583/
https://ncbi.nlm.nih.gov/pubmed/26279568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.07.039
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