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Intramolecular C2 Domain-Mediated Autoinhibition of Protein Kinase C βII
The signaling output of protein kinase C (PKC) is exquisitely controlled, with its disruption resulting in pathophysiologies. Identifying the structural basis for autoinhibition is central to developing effective therapies for cancer, where PKC activity needs to be enhanced, or neurodegenerative dis...
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| 發表在: | Cell Rep |
|---|---|
| Main Authors: | , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4551583/ https://ncbi.nlm.nih.gov/pubmed/26279568 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.07.039 |
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