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Intramolecular C2 Domain-Mediated Autoinhibition of Protein Kinase C βII
The signaling output of protein kinase C (PKC) is exquisitely controlled, with its disruption resulting in pathophysiologies. Identifying the structural basis for autoinhibition is central to developing effective therapies for cancer, where PKC activity needs to be enhanced, or neurodegenerative dis...
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| Vydáno v: | Cell Rep |
|---|---|
| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4551583/ https://ncbi.nlm.nih.gov/pubmed/26279568 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.07.039 |
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