Active Site Inhibitors Protect Protein Kinase C from Dephosphorylation and Stabilize Its Mature Form

Conformational changes acutely control protein kinase C (PKC). We have previously shown that the autoinhibitory pseudosubstrate must be removed from the active site in order for 1) PKC to be phosphorylated by its upstream kinase phosphoinositide-dependent kinase 1 (PDK-1), 2) the mature enzyme to bi...

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Detalhes bibliográficos
Main Authors: Gould, Christine M., Antal, Corina E., Reyes, Gloria, Kunkel, Maya T., Adams, Ryan A., Ziyar, Ahdad, Riveros, Tania, Newton, Alexandra C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190699/
https://ncbi.nlm.nih.gov/pubmed/21715334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.272526
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