The Protein Scaffold NHERF-1 Controls the Amplitude and Duration of Localized Protein Kinase D Activity

Protein kinase D (PKD) transduces an abundance of signals downstream of diacylglycerol production. The mammalian PKD family consists of three isoforms, PKD1, PKD2, and PKD3; of these PKD1 and PKD2 contain PDZ-binding motifs at their carboxyl termini. Here we show that membrane-localized NHERF scaffo...

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Détails bibliographiques
Auteurs principaux: Kunkel, Maya T., Garcia, Erin L., Kajimoto, Taketoshi, Hall, Randy A., Newton, Alexandra C.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2009
Sujets:
Mechanisms of Signal Transduction
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782054/
https://ncbi.nlm.nih.gov/pubmed/19581308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.024547
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