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Protein Scaffolds Control Localized Protein Kinase Cζ Activity

Atypical protein kinase C (aPKC) isozymes modulate insulin signaling and cell polarity, but how their activity is controlled in cells is not well understood. These enzymes are constitutively phosphorylated, insensitive to second messengers, and have relatively low activity. Here we show that protein...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Tobias, Irene S., Newton, Alexandra C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4919463/
https://ncbi.nlm.nih.gov/pubmed/27143478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.729483
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