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An ALS disease mutation in Cdc48/p97 impairs 20S proteasome binding and proteolytic communication
Cdc48 (also known as p97 or VCP) is an essential and highly abundant, double-ring AAA+ ATPase, which is ubiquitous in archaea and eukaryotes. In archaea, Cdc48 ring hexamers play a direct role in quality control by unfolding and translocating protein substrates into the degradation chamber of the 20...
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| Publicado no: | Protein Sci |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley & Sons, Ltd
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4570545/ https://ncbi.nlm.nih.gov/pubmed/26134898 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2740 |
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