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Identification of the Cdc48•20S Proteasome as an Ancient AAA+ Proteolytic Machine
Proteasomes are the major ATP-dependent proteolytic machines in the eukaryotic and archaeal domains of life. To execute protein degradation, the 20S core peptidase combines with the AAA+ ring of the 19S regulatory particle in eukarya or with the AAA+ PAN ring in some archaea. Here, we find that Cdc4...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3923512/ https://ncbi.nlm.nih.gov/pubmed/22837385 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1224352 |
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