The tRNA methyltransferase Dnmt2 is required for accurate polypeptide synthesis during haematopoiesis

The Dnmt2 enzyme utilizes the catalytic mechanism of eukaryotic DNA methyltransferases to methylate several tRNAs at cytosine 38. Dnmt2 mutant mice, flies, and plants were reported to be viable and fertile, and the biological function of Dnmt2 has remained elusive. Here, we show that endochondral os...

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Pubblicato in:EMBO J
Autori principali: Tuorto, Francesca, Herbst, Friederike, Alerasool, Nader, Bender, Sebastian, Popp, Oliver, Federico, Giuseppina, Reitter, Sonja, Liebers, Reinhard, Stoecklin, Georg, Gröne, Hermann-Josef, Dittmar, Gunnar, Glimm, Hanno, Lyko, Frank
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley & Sons, Ltd 2015
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4570521/
https://ncbi.nlm.nih.gov/pubmed/26271101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201591382
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