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The β-cell GHSR and downstream cAMP/TRPM2 signaling account for insulinostatic and glycemic effects of ghrelin

Gastric hormone ghrelin regulates insulin secretion, as well as growth hormone release, feeding behavior and adiposity. Ghrelin is known to exert its biological actions by interacting with the growth hormone secretagogue-receptor (GHSR) coupled to G(q/11)-protein signaling. By contrast, ghrelin acts...

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מידע ביבליוגרפי
הוצא לאור ב:Sci Rep
Main Authors: Kurashina, Tomoyuki, Dezaki, Katsuya, Yoshida, Masashi, Sukma Rita, Rauza, Ito, Kiyonori, Taguchi, Masanobu, Miura, Rina, Tominaga, Makoto, Ishibashi, Shun, Kakei, Masafumi, Yada, Toshihiko
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Publishing Group 2015
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4570196/
https://ncbi.nlm.nih.gov/pubmed/26370322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14041
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