Lack of TRPM2 Impaired Insulin Secretion and Glucose Metabolisms in Mice

OBJECTIVE: TRPM2 is a Ca(2+)-permeable nonselective cation channel activated by adenosine dinucleotides. We previously demonstrated that TRPM2 is activated by coapplication of heat and intracellular cyclic adenosine 5′-diphosphoribose, which has been suggested to be involved in intracellular Ca(2+)...

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Detalhes bibliográficos
Main Authors: Uchida, Kunitoshi, Dezaki, Katsuya, Damdindorj, Boldbaatar, Inada, Hitoshi, Shiuchi, Tetsuya, Mori, Yasuo, Yada, Toshihiko, Minokoshi, Yasuhiko, Tominaga, Makoto
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2011
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012163/
https://ncbi.nlm.nih.gov/pubmed/20921208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-0276
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