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TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion

There are eight thermosensitive TRP (transient receptor potential) channels in mammals, and there might be other TRP channels sensitive to temperature stimuli. Here, we demonstrate that TRPM2 can be activated by exposure to warm temperatures (>35°C) apparently via direct heat-evoked channel gatin...

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Detalhes bibliográficos
Main Authors: Togashi, Kazuya, Hara, Yuji, Tominaga, Tomoko, Higashi, Tomohiro, Konishi, Yasunobu, Mori, Yasuo, Tominaga, Makoto
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1456947/
https://ncbi.nlm.nih.gov/pubmed/16601673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601083
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