The β-cell GHSR and downstream cAMP/TRPM2 signaling account for insulinostatic and glycemic effects of ghrelin

Gastric hormone ghrelin regulates insulin secretion, as well as growth hormone release, feeding behavior and adiposity. Ghrelin is known to exert its biological actions by interacting with the growth hormone secretagogue-receptor (GHSR) coupled to G(q/11)-protein signaling. By contrast, ghrelin acts...

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Gepubliceerd in:Sci Rep
Hoofdauteurs: Kurashina, Tomoyuki, Dezaki, Katsuya, Yoshida, Masashi, Sukma Rita, Rauza, Ito, Kiyonori, Taguchi, Masanobu, Miura, Rina, Tominaga, Makoto, Ishibashi, Shun, Kakei, Masafumi, Yada, Toshihiko
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4570196/
https://ncbi.nlm.nih.gov/pubmed/26370322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14041
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