Ghrelin Attenuates cAMP-PKA Signaling to Evoke Insulinostatic Cascade in Islet β-Cells

OBJECTIVE: Ghrelin reportedly restricts insulin release in islet β-cells via the Gα(i2) subtype of G-proteins and thereby regulates glucose homeostasis. This study explored whether ghrelin regulates cAMP signaling and whether this regulation induces insulinostatic cascade in islet β-cells. RESEARCH...

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Hlavní autoři: Dezaki, Katsuya, Damdindorj, Boldbaatar, Sone, Hideyuki, Dyachok, Oleg, Tengholm, Anders, Gylfe, Erik, Kurashina, Tomoyuki, Yoshida, Masashi, Kakei, Masafumi, Yada, Toshihiko
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2011
Témata:
Islet Studies
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3161328/
https://ncbi.nlm.nih.gov/pubmed/21788571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0368
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