Strain-Dependent Effect of Macroautophagy on Abnormally Folded Prion Protein Degradation in Infected Neuronal Cells

Prion diseases are neurodegenerative disorders caused by the accumulation of abnormal prion protein (PrP(Sc)) in the central nervous system. With the aim of elucidating the mechanism underlying the accumulation and degradation of PrP(Sc), we investigated the role of autophagy in its degradation, usi...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Ishibashi, Daisuke, Homma, Takujiro, Nakagaki, Takehiro, Fuse, Takayuki, Sano, Kazunori, Takatsuki, Hanae, Atarashi, Ryuichiro, Nishida, Noriyuki
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4569470/
https://ncbi.nlm.nih.gov/pubmed/26368533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0137958
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