Strain-Dependent Effect of Macroautophagy on Abnormally Folded Prion Protein Degradation in Infected Neuronal Cells

Prion diseases are neurodegenerative disorders caused by the accumulation of abnormal prion protein (PrP(Sc)) in the central nervous system. With the aim of elucidating the mechanism underlying the accumulation and degradation of PrP(Sc), we investigated the role of autophagy in its degradation, usi...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Ishibashi, Daisuke, Homma, Takujiro, Nakagaki, Takehiro, Fuse, Takayuki, Sano, Kazunori, Takatsuki, Hanae, Atarashi, Ryuichiro, Nishida, Noriyuki
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2015
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4569470/
https://ncbi.nlm.nih.gov/pubmed/26368533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0137958
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