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Strain-Dependent Effect of Macroautophagy on Abnormally Folded Prion Protein Degradation in Infected Neuronal Cells
Prion diseases are neurodegenerative disorders caused by the accumulation of abnormal prion protein (PrP(Sc)) in the central nervous system. With the aim of elucidating the mechanism underlying the accumulation and degradation of PrP(Sc), we investigated the role of autophagy in its degradation, usi...
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| Опубликовано в: : | PLoS One |
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| Главные авторы: | , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Public Library of Science
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4569470/ https://ncbi.nlm.nih.gov/pubmed/26368533 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0137958 |
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