Strain-Dependent Effect of Macroautophagy on Abnormally Folded Prion Protein Degradation in Infected Neuronal Cells

Prion diseases are neurodegenerative disorders caused by the accumulation of abnormal prion protein (PrP(Sc)) in the central nervous system. With the aim of elucidating the mechanism underlying the accumulation and degradation of PrP(Sc), we investigated the role of autophagy in its degradation, usi...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Ishibashi, Daisuke, Homma, Takujiro, Nakagaki, Takehiro, Fuse, Takayuki, Sano, Kazunori, Takatsuki, Hanae, Atarashi, Ryuichiro, Nishida, Noriyuki
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4569470/
https://ncbi.nlm.nih.gov/pubmed/26368533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0137958
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