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In vitro and in vivo Evaluation of Synergism between Anti-Tubercular Spectinamides and Non-Classical Tuberculosis Antibiotics

Spectinamides are new semi-synthetic spectinomycin derivatives with potent anti-tubercular activity. The reported synergism of the precursor spectinomycin with other antibiotics prompted us to examine whether spectinamides sensitize M. tuberculosis to other antibiotics not traditionally used in the...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Bruhn, David F., Scherman, Michael S., Liu, Jiuyu, Scherbakov, Dimitri, Meibohm, Bernd, Böttger, Erik C., Lenaerts, Anne J., Lee, Richard E.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2015
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4568539/
https://ncbi.nlm.nih.gov/pubmed/26365087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep13985
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