Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1

Electrophilic compounds are a newly recognized class of redox-active neuroprotective compounds with electron deficient, electrophilic carbon centers that react with specific cysteine residues on targeted proteins via thiol (S-)alkylation. Although plants produce a variety of physiologically active e...

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Publicat a:J Neurochem
Autors principals: Satoh, T, Kosaka, K, Itoh, K, Kobayashi, A, Yamamoto, M, Shimojo, Y, Kitajima, C, Cui, J, Kamins, J, Okamoto, S, Izumi, M, Shirasawa, T, Lipton, SA.
Format: Artigo
Idioma:Inglês
Publicat: 2007
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4566957/
https://ncbi.nlm.nih.gov/pubmed/17995931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2007.05039.x
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