Divergent Roles of CAAX Motif-signaled Posttranslational Modifications in the Regulation and Subcellular Localization of Ral GTPases

The Ras-like small GTPases RalA and RalB are well validated effectors of RAS oncogene-driven human cancer growth, and pharmacologic inhibitors of Ral function may provide an effective anti-Ras therapeutic strategy. Intriguingly, although RalA and RalB share strong overall amino acid sequence identit...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Gentry, Leanna R., Nishimura, Akiyuki, Cox, Adrienne D., Martin, Timothy D., Tsygankov, Denis, Nishida, Motohiro, Elston, Timothy C., Der, Channing J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2015
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4566255/
https://ncbi.nlm.nih.gov/pubmed/26216878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.656710
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