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Differential Requirement of CAAX-mediated Posttranslational Processing for Rheb Localization and Signaling
The Rheb1 and Rheb2 small GTPases and their effector mTOR are aberrantly activated in human cancer and are attractive targets for anti-cancer drug discovery. Rheb is targeted to endomembranes via its C-terminal CAAX (C = cysteine, A = aliphatic, X = terminal amino acid) motif, a substrate for posttr...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2809798/ https://ncbi.nlm.nih.gov/pubmed/19838215 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.336 |
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