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The Ras-related small GTPases RalA and RalB regulate cellular survival after ionizing radiation

PURPOSE: Oncogenic activation of Ras renders cancer cells resistant to ionizing radiation (IR), but the mechanisms have not been fully characterized. The Ras-like small GTPases, RalA and RalB, are downstream effectors of Ras function and are critical for both tumor growth and survival. The Ral effec...

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Detalhes bibliográficos
Main Authors: Kidd, Ambrose R., Snider, Jared L., Martin, Timothy D., Graboski, Sarah F., Der, Channing J., Cox, Adrienne D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2922474/
https://ncbi.nlm.nih.gov/pubmed/20619549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2010.03.023
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