Geranylgeranyltransferase I Inhibitors Target RalB To Inhibit Anchorage-Dependent Growth and Induce Apoptosis and RalA To Inhibit Anchorage-Independent Growth

Geranylgeranyltransferase I inhibitors (GGTIs) are presently undergoing advanced preclinical studies and have been shown to disrupt oncogenic and tumor survival pathways, to inhibit anchorage-dependent and -independent growth, and to induce apoptosis. However, the geranylgeranylated proteins that ar...

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Bibliographic Details
Main Authors: Falsetti, Samuel C., Wang, De-an, Peng, Hairuo, Carrico, Dora, Cox, Adrienne D., Der, Channing J., Hamilton, Andrew D., Sebti, Saïd M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2007
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2169159/
https://ncbi.nlm.nih.gov/pubmed/17875936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00057-07
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