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Reverse engineering of logic-based differential equation models using a mixed-integer dynamic optimization approach

Motivation: Systems biology models can be used to test new hypotheses formulated on the basis of previous knowledge or new experimental data, contradictory with a previously existing model. New hypotheses often come in the shape of a set of possible regulatory mechanisms. This search is usually not...

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Detalhes bibliográficos
Publicado no:Bioinformatics
Main Authors: Henriques, David, Rocha, Miguel, Saez-Rodriguez, Julio, Banga, Julio R.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4565031/
https://ncbi.nlm.nih.gov/pubmed/26002881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btv314
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