Generation of gene-modified goats targeting MSTN and FGF5 via zygote injection of CRISPR/Cas9 system

Recent advances in the study of the CRISPR/Cas9 system have provided a precise and versatile approach for genome editing in various species. However, the applicability and efficiency of this method in large animal models, such as the goat, have not been extensively studied. Here, by co-injection of...

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Publicado no:Sci Rep
Main Authors: Wang, Xiaolong, Yu, Honghao, Lei, Anmin, Zhou, Jiankui, Zeng, Wenxian, Zhu, Haijing, Dong, Zhiming, Niu, Yiyuan, Shi, Bingbo, Cai, Bei, Liu, Jinwang, Huang, Shuai, Yan, Hailong, Zhao, Xiaoe, Zhou, Guangxian, He, Xiaoling, Chen, Xiaoxu, Yang, Yuxin, Jiang, Yu, Shi, Lei, Tian, Xiue, Wang, Yongjun, Ma, Baohua, Huang, Xingxu, Qu, Lei, Chen, Yulin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4564737/
https://ncbi.nlm.nih.gov/pubmed/26354037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep13878
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