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High-throughput determination of RNA structure by proximity ligation

We present an unbiased method to globally resolve RNA structures through pairwise contact measurements between interacting regions. RNA Proximity Ligation (RPL) uses proximity ligation of native RNA followed by deep sequencing to yield chimeric reads with ligation junctions in the vicinity of struct...

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Detalhes bibliográficos
Publicado no:Nat Biotechnol
Main Authors: Ramani, Vijay, Qiu, Ruolan, Shendure, Jay
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4564351/
https://ncbi.nlm.nih.gov/pubmed/26237516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3289
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