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Nanoformulation of Geranylgeranyltransferase-I Inhibitors for Cancer Therapy: Liposomal Encapsulation and pH-Dependent Delivery to Cancer Cells

Small molecule inhibitors against protein geranylgeranyltransferase-I such as P61A6 have been shown to inhibit proliferation of a variety of human cancer cells and exhibit antitumor activity in mouse models. Development of these inhibitors could be dramatically accelerated by conferring tumor target...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Lu, Jie, Yoshimura, Kohei, Goto, Koichi, Lee, Craig, Hamura, Ken, Kwon, Ohyun, Tamanoi, Fuyuhiko
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4564137/
https://ncbi.nlm.nih.gov/pubmed/26352258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0137595
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