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Small-Molecule Inhibitors of Protein Geranylgeranyltransferase Type I
[Image: see text] Small molecules that inhibit the geranylgeranylation of K-Ras4B and RhoA by protein geranylgeranyltransferase type I (GGTase-I) were identified from chemical genetic screens of heterocycles synthesized through phosphine catalysis of allenes. To further improve the efficacy of the G...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2543057/ https://ncbi.nlm.nih.gov/pubmed/17439124 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja070274n |
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