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Small-Molecule Inhibitors of Protein Geranylgeranyltransferase Type I

[Image: see text] Small molecules that inhibit the geranylgeranylation of K-Ras4B and RhoA by protein geranylgeranyltransferase type I (GGTase-I) were identified from chemical genetic screens of heterocycles synthesized through phosphine catalysis of allenes. To further improve the efficacy of the G...

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Bibliografiske detaljer
Main Authors: Castellano, Sabrina, Fiji, Hannah D. G., Kinderman, Sape S., Watanabe, Masaru, de Leon, Pablo, Tamanoi, Fuyuhiko, Kwon, Ohyun
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2543057/
https://ncbi.nlm.nih.gov/pubmed/17439124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja070274n
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