Inhibitors of Protein Geranylgeranyltransferase I and Rab Geranylgeranyltransferase Identified from a Library of Allenoate-derived Compounds

Protein geranylgeranylation is critical for the function of a number of proteins such as RhoA, Rac, and Rab. Protein geranylgeranyltransferase I (GGTase-I) and Rab geranylgeranyltransferase (RabGGTase) catalyze these modifications. In this work, we first describe the identification and characterizat...

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Detalhes bibliográficos
Main Authors: Watanabe, Masaru, Fiji, Hannah D. G., Guo, Lea, Chan, Lai, Kinderman, Sape S., Slamon, Dennis J., Kwon, Ohyun, Tamanoi, Fuyuhiko
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Protein Synthesis, Post-Translation Modification, and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442295/
https://ncbi.nlm.nih.gov/pubmed/18230616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M706229200
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