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MEK guards proteome stability and inhibits tumor-suppressive amyloidogenesis via HSF1
Signaling through RAS/MAP kinase pathway is central to biology. ERK has long been perceived as the only substrate for MEK. Herein we report that HSF1, the master regulator of the proteotoxic stress response, is a new MEK substrate. Beyond mediating cell-environment interactions, the MEK-HSF1 regulat...
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| Publicado no: | Cell |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4564124/ https://ncbi.nlm.nih.gov/pubmed/25679764 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.01.028 |
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