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HSF1 physically neutralizes amyloid oligomers to empower overgrowth and bestow neuroprotection
The role of proteomic instability in cancer, particularly amyloidogenesis, remains obscure. Heat shock factor 1 (HSF1) transcriptionally governs the proteotoxic stress response to suppress proteomic instability and enhance survival. Paradoxically, HSF1 promotes oncogenesis. Here, we report that AKT...
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| Publicado no: | Sci Adv |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Association for the Advancement of Science
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7673739/ https://ncbi.nlm.nih.gov/pubmed/33177089 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abc6871 |
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