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HSF1 critically attunes proteotoxic-stress sensing by mTORC1 to combat stress and promote growth
To cope with proteotoxic stress, cells attenuate protein synthesis. However, the precise mechanisms underlying this fundamental adaptation remain poorly defined. Here we report that mTORC1 acts as an immediate cellular sensor of proteotoxic stress. Surprisingly, the multifaceted stress-responsive ki...
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| Publicado no: | Nat Cell Biol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5341796/ https://ncbi.nlm.nih.gov/pubmed/27043084 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3335 |
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