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Suppression of the HSF1-mediated proteotoxic stress response by the metabolic stress sensor AMPK

Numerous extrinsic and intrinsic insults trigger the HSF1-mediated proteotoxic stress response (PSR), an ancient transcriptional program that is essential to proteostasis and survival under such conditions. In contrast to its well-recognized mobilization by proteotoxic stress, little is known about...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:EMBO J
Hauptverfasser: Dai, Siyuan, Tang, Zijian, Cao, Junyue, Zhou, Wei, Li, Huawen, Sampson, Stephen, Dai, Chengkai
Format: Artigo
Sprache:Inglês
Veröffentlicht: BlackWell Publishing Ltd 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4339117/
https://ncbi.nlm.nih.gov/pubmed/25425574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201489062
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