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Molecular overlap in the regulation of SK channels by small molecules and phosphoinositides
Phosphatidylinositol 4,5-bisphosphate (PIP(2)) directly interacts with the small-conductance Ca(2+)-activated K(+) 2-a (SK2-a) channel/calmodulin complex, serving as a critical element in the regulation of channel activity. We report that changes of protein conformation in close proximity to the PIP...
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| Publicado no: | Sci Adv |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Association for the Advancement of Science
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4563807/ https://ncbi.nlm.nih.gov/pubmed/26366439 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1500008 |
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