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The Molecular Mechanism by which PIP(2) Opens the Intracellular G-Loop Gate of a Kir3.1 Channel
Inwardly rectifying potassium (Kir) channels are characterized by a long pore comprised of continuous transmembrane and cytosolic portions. A high-resolution structure of a Kir3.1 chimera revealed the presence of the cytosolic (G-loop) gate captured in the closed or open conformations. Here, we cond...
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| Asıl Yazarlar: | , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
The Biophysical Society
2012
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3341553/ https://ncbi.nlm.nih.gov/pubmed/22824268 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.03.050 |
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