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The Molecular Mechanism by which PIP(2) Opens the Intracellular G-Loop Gate of a Kir3.1 Channel

Inwardly rectifying potassium (Kir) channels are characterized by a long pore comprised of continuous transmembrane and cytosolic portions. A high-resolution structure of a Kir3.1 chimera revealed the presence of the cytosolic (G-loop) gate captured in the closed or open conformations. Here, we cond...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Meng, Xuan-Yu, Zhang, Hong-Xing, Logothetis, Diomedes E., Cui, Meng
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Biophysical Society 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3341553/
https://ncbi.nlm.nih.gov/pubmed/22824268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.03.050
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