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Identification of the Conformational transition pathway in PIP(2) Opening Kir Channels
The gating of Kir channels depends critically on phosphatidylinositol 4,5-bisphosphate (PIP(2)), but the detailed mechanism by which PIP(2) regulates Kir channels remains obscure. Here, we performed a series of Targeted molecular dynamics simulations on the full-length Kir2.1 channel and, for the fi...
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| 發表在: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4462750/ https://ncbi.nlm.nih.gov/pubmed/26063437 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep11289 |
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