Identification of the Conformational transition pathway in PIP(2) Opening Kir Channels

The gating of Kir channels depends critically on phosphatidylinositol 4,5-bisphosphate (PIP(2)), but the detailed mechanism by which PIP(2) regulates Kir channels remains obscure. Here, we performed a series of Targeted molecular dynamics simulations on the full-length Kir2.1 channel and, for the fi...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Li, Junwei, Lü, Shouqin, Liu, Yuzhi, Pang, Chunli, Chen, Yafei, Zhang, Suhua, Yu, Hui, Long, Mian, Zhang, Hailin, Logothetis, Diomedes E., Zhan, Yong, An, Hailong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4462750/
https://ncbi.nlm.nih.gov/pubmed/26063437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep11289
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