Lack of Negatively Charged Residues at the External Mouth of Kir2.2 Channels Enable the Voltage-Dependent Block by External Mg(2+)

Kir channels display voltage-dependent block by cytosolic cations such as Mg(2+) and polyamines that causes inward rectification. In fact, cations can regulate K channel activity from both the extracellular and intracellular sides. Previous studies have provided insight into the up-regulation of Kir...

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Detalhes bibliográficos
Main Authors: Li, Junwei, Xie, Xiaoxiao, Liu, Jun, Yu, Hui, Zhang, Suhua, Zhan, Yong, Zhang, Hailin, Logothetis, Diomedes E., An, Hailong
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4211740/
https://ncbi.nlm.nih.gov/pubmed/25350118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0111372
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