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Molecular overlap in the regulation of SK channels by small molecules and phosphoinositides

Phosphatidylinositol 4,5-bisphosphate (PIP(2)) directly interacts with the small-conductance Ca(2+)-activated K(+) 2-a (SK2-a) channel/calmodulin complex, serving as a critical element in the regulation of channel activity. We report that changes of protein conformation in close proximity to the PIP...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Adv
Prif Awduron: Zhang, Miao, Meng, Xuan-Yu, Zhang, Ji-fang, Cui, Meng, Logothetis, Diomedes E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Association for the Advancement of Science 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4563807/
https://ncbi.nlm.nih.gov/pubmed/26366439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1500008
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