Affinity-seq detects genome-wide PRDM9 binding sites and reveals the impact of prior chromatin modifications on mammalian recombination hotspot usage

BACKGROUND: Genetic recombination plays an important role in evolution, facilitating the creation of new, favorable combinations of alleles and the removal of deleterious mutations by unlinking them from surrounding sequences. In most mammals, the placement of genetic crossovers is determined by the...

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Detalhes bibliográficos
Publicado no:Epigenetics Chromatin
Main Authors: Walker, Michael, Billings, Timothy, Baker, Christopher L., Powers, Natalie, Tian, Hui, Saxl, Ruth L., Choi, Kwangbom, Hibbs, Matthew A., Carter, Gregory W., Handel, Mary Ann, Paigen, Kenneth, Petkov, Petko M.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4562113/
https://ncbi.nlm.nih.gov/pubmed/26351520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13072-015-0024-6
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