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Recruitment and activation of the ATM kinase in the absence of DNA damage sensors
Two kinases, ATM and DNA-PKcs, control rapid responses to DNA double-strand breaks (DSBs). The paradigm for ATM control is recruitment and activation by the Mre11–Rad50–NBS1 (MRN) sensor complex, whereas DNA-PKcs requires the sensor Ku (Ku70–Ku80). Using Mus musculus cells harboring targeted mutant...
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| Pubblicato in: | Nat Struct Mol Biol |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4560612/ https://ncbi.nlm.nih.gov/pubmed/26280532 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3072 |
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