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Disease-associated MRE11 mutants impact ATM/ATR DNA damage signaling by distinct mechanisms
DNA double-strand breaks (DSBs) can lead to instability of the genome if not repaired correctly. The MRE11/RAD50/NBS1 (MRN) complex binds DSBs and initiates damage-induced signaling cascades via activation of the ataxia-telangiectasia mutated (ATM) and ataxia-telangiectasia- and rad3-related (ATR) k...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3842175/ https://ncbi.nlm.nih.gov/pubmed/23912341 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt368 |
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