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Colocalization of Sensors Is Sufficient to Activate the DNA Damage Checkpoint in the Absence of Damage

Previous work on the DNA damage checkpoint in Saccharomyces cerevisiae has shown that two complexes independently sense DNA lesions: the kinase Mec1-Ddc2 and the PCNA-like 9-1-1 complex. To test whether colocalization of these components is sufficient for checkpoint activation, we fused these checkp...

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Bibliografiske detaljer
Main Authors: Bonilla, Carla Yaneth, Melo, Justine Amy, Toczyski, David Paul
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2879338/
https://ncbi.nlm.nih.gov/pubmed/18471973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.03.023
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