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Colocalization of Sensors Is Sufficient to Activate the DNA Damage Checkpoint in the Absence of Damage
Previous work on the DNA damage checkpoint in Saccharomyces cerevisiae has shown that two complexes independently sense DNA lesions: the kinase Mec1-Ddc2 and the PCNA-like 9-1-1 complex. To test whether colocalization of these components is sufficient for checkpoint activation, we fused these checkp...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2879338/ https://ncbi.nlm.nih.gov/pubmed/18471973 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.03.023 |
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