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DNA Damage-Induced Acetylation of Lysine 3016 of ATM Activates ATM Kinase Activity

The ATM protein kinase is essential for cells to repair and survive genotoxic events. The activation of ATM's kinase activity involves acetylation of ATM by the Tip60 histone acetyltransferase. In this study, systematic mutagenesis of lysine residues was used to identify regulatory ATM acetylat...

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Bibliografiske detaljer
Main Authors: Sun, Yingli, Xu, Ye, Roy, Kanaklata, Price, Brendan D.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2169409/
https://ncbi.nlm.nih.gov/pubmed/17923702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01382-07
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