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Acetylation of H2AX on lysine 36 plays a key role in the DNA double-strand break repair pathway
Phosphorylation of H2AX functions to recruit DNA repair complexes to sites of DNA damage. Here, we report that H2AX is constitutively acetylated on lysine 36 (H2AXK36Ac) by the CBP/p300 acetyltransferases. H2AXK36Ac is required for cells to survive exposure to ionizing radiation; however, H2AXK36Ac...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2887596/ https://ncbi.nlm.nih.gov/pubmed/20488183 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2010.05.017 |
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