Kinetic fingerprinting to identify and count single nucleic acids

MicroRNAs (miRNAs) have emerged as promising diagnostic biomarkers. We introduce a kinetic fingerprinting approach called Single Molecule Recognition through Equilibrium Poisson Sampling (SiMREPS) for the amplification-free counting of single unlabeled miRNA molecules, which circumvents thermodynami...

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Bibliographic Details
Published in:Nat Biotechnol
Main Authors: Johnson-Buck, Alexander, Su, Xin, Giraldez, Maria D., Zhao, Meiping, Tewari, Muneesh, Walter, Nils G.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4559481/
https://ncbi.nlm.nih.gov/pubmed/26098451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3246
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